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Topiramate has similar benefits for weight reduction in psychiatric patients, but cognitive impairment limits its usage (McIntyre RS et al, Am J Psychiatry 2024;181(1):2638)
The dose escalation protocol exists specifically to minimize these effects by allowing gradual adaptation
Bariatric surgery is associated with both reduced cancer risk and mortality, demonstrating the potential for sustained weight loss to improve cancer outcomes 11,12
Magnesium supplementation should be individualized based on laboratory results rather than routinely recommended, particularly in patients with kidney disease
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