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Non-esterified fatty acids (NEFAs) activate the TLR4/NF-B pathway in granulosa cells, increasing NLRP3 and caspase-1 levels, along with the release of IL-1 and IL-6, leading to OS, pyroptosis, and inflammation (Wang Y
Subsequently, biodistribution studies of DSePA were carried out in a mice model, which indicated that DSePA was maximally absorbed in the lung tissues [90]
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