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The organic layer was dried over anhydrous NaSO, filtered, and concentrated under reduced pressure to obtain Compound 6 (yield: 85%)

Under homeostatic conditions, transient activation of NRF2 is cytoprotective, allowing for adaptation to various cell intrinsic (i.e., reactive oxygen species (ROS) generated by mitochondrial function) and extrinsic (i.e., xenobiotic) stressors (Kensler et al, 2007