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Crucially, many trials may have included older adults, but had an upper age limit in their inclusion/exclusion criteria, resulting in little data for people in their 80s

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Bupropion may slightly reduce semaglutide's appetite suppression for some patients, while mirtazapine is known for increasing appetite and weight gain independentlycombining it with semaglutide requires proactive monitoring and may necessitate mirtazapine dose reduction or medication switching