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Timing and Frequency Considerations: AOD-9604 is most commonly administered once daily in the morning on an empty stomach to maximize absorption and align with natural circadian metabolic rhythms

8 weeks: ~3 vials 12 weeks: ~4 vials 16 weeks: ~6 vials Insulin Syringes (U-100, 1 mL) Per week (once daily): 7 syringes 8 weeks: 56 syringes 12 weeks: 84 syringes 16 weeks: 112 syringes Bacteriostatic Water (10 mL bottles) Use ~3.0 mL per 10 mg vial for reconstitution

Levels of serum cobalamin are not easily correlated with clinical symptoms