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In addition, cyclic diGMP (c-di-GMP) is considered to be an anti-cancer adjuvant and which is a ligand for the interferon gene stimulator (STING) signaling pathway, when it was encapsulated in YSK05 liposome to form c-di-GMP/YSK05-Lip nanoparticles which can effectively induce the production of type I IFN and activate NK cells in mouse, and induce NK cell-mediated MHC-I non-restricted anti-tumor immunity to produce significant anti-tumor effects (89)

This may vary from person to person due to the amount of vitamin C in the formula which may prove too potent

However, no human studies have examined truly long-term use extending over years or decades

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