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In clinical trials such as the STEP programme for semaglutide 2.4mg (Wegovy), fatigue was reported more frequently in patients receiving the active treatment compared to placebo
Some participants lost over 30% (Jastreboff et al., NEJM 2023)
These pharmacologic doses support immune defense, collagen synthesis, oxidative stress reduction, and at very high levels may exert selective cytotoxic effects against abnormal cells
Survodutide is a candidate drug in the obesity treatment pipeline, belonging to a class of dual GLP-1 and GCGR agonists
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