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Phase II clinical trial results demonstrated: Body weight reduction of up to 2% at 48 weeks (vs 2.1% placebo) 83% of participants achieved 15% body weight loss at 12 mg weekly dose HbA1c reduction of up to 02% in participants with Type 2 Diabetes Normalization of liver fat in 86% of participants with hepatic steatosis Reduction in systolic blood pressure averaging 6-8 mmHg preliminary

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For the nuclear intensity, circle the nuclear region was circled based on DAPI channel, and then, the ROI circled based on DAPI staining was selected for the target fluorescence channel (red) to calculate the nuclear intensity