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In the MAPK pathway, clinical evaluation includes agents such as LY3009120 (NCT02014116) and ulixertinib in combination with palbociclib (NCT03454035) for patients with advanced pancreatic and other refractory solid tumors

A systematic review of studies that examined GLP-1 and GLP-1RA-mediated functional connectivity changes in adults included 8 primary or secondary studies that examined the role of GLP-1 and GLP-1RAs in functional connectivity [26]

This is particularly relevant in muscle and cardiovascular research models