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Clinical studies show semaglutide leads to an average weight loss of 15% to 20% when paired with healthy lifestyle changes

For example, patients who are being prescribed GLP-1s are more likely to get coverage if they also have preexisting conditions such as type 2 diabetes, hypertension, cardiovascular disease, and the like

Oral medications such as phentermine or topiramate often produce early appetite control and can support steady monthly reductions in weight when paired with consistent follow-up

Additionally, the FDA approved the Wegovy pill in December 2025, offering an oral semaglutide option for those who prefer to avoid injections