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A 2017 review summarised neuroprotective properties of silymarin in animal models, including: Reduction of amyloidogenic activity (relevant in Alzheimer's research) Anti-inflammatory action in nerve tissue Reduction of oxidative stress in the brain Possible positive effects on cognitive function Possible reduction of stroke risk Whether these effects can be achieved in humans at attainable concentrations of silymarin in particular whether sufficient quantities can cross the blood-brain barrier remains unclear

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The dose can be increased to 2.0mg for a further month and then a maximum of 2.4mg weekly

An AMP nucleosidase gene knockout in Escherichia coli elevates intracellular ATP levels and increases cold tolerance