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QPCR results revealed a significant downregulation in CCS52B expression, whereas the reduction in CCS52A1 and CCS52A2 expression was insignificant ( P -value 0.372 and 0.382, respectively)
The pivotal STEP trials for semaglutide and SURMOUNT trials for tirzepatide included thousands of participants with monitoring for suicidal ideation using standardized tools such as the Columbia-Suicide Severity Rating Scale (C-SSRS), and did not demonstrate elevated rates compared to placebo groups
Most continue normal routines and soon experience more consistent energy, improved mood, and a stronger metabolism
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