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Most patients notice marked improvements after several weeks of consistent use and careful dose adjustment
A 2021 study published in the New England Journal of Medicine (Wilding et al., NEJM, 2021) found that semaglutide 2.4 mg produced an average weight loss of approximately 14.9% of body weight over 68 weeks in adults with obesity, compared to 2.4% in the placebo group
Key Facts A phase three clinical trial on Saxenda found suicidal thoughts were one of the drugs most severe side effectsother serious side effects include renal impairment, pancreatitis and gallbladder disease
Its long-term effect makes it possible to observe a gradual change over time, giving information about the immediate and the long-term metabolic reactions
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