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How semaglutide affects body weight and appetite Semaglutide's effectiveness in supporting your weight loss journey comes from its sophisticated interaction with your body's natural systems

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Realistic 2026 Results: What the Data Shows Metric Typical IF Outcome (1012 Weeks) Weight Loss 711 pounds (roughly 35% of body weight) Fat Loss Primarily visceral (belly) fat Blood Pressure Significant reductions in those with high baseline levels Muscle Retention High (if paired with resistance training) Reduced calorie intake due to fewer meals Improved insulin sensitivity Increased fat burning during fasting periods However, IF does not directly suppress appetite, which is why many people struggle with hunger during fasting hours

Bachem MG, Schneider E, Gross H et al