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WT and C25H KO mice were injected intraperitoneally with MDP (20 mg/kg)
EPA is also a cyclooxygenase substrate for the biosynthesis of PGE3 which also exert inflammatory activity, albeit PGE3 biosynthesis occurs with very low efficiency [5]
Because it activates both, it's often called a "dual agonist." The FDA has described tirzepatide (brand name Zepbound) as the first medication of its kind to activate both of these receptors for weight management, and it was approved for that use in November 2023
10.1093/cid/cir500 12
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