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The Discovery Rabbit Thalamic Stimulation (1977) The original 1977 isolation by the Schoenenberger-Monnier group at Basel confirmed DSIP as a nonapeptide of MW 849 Da inducing primarily delta-sleep in rabbits, rats, mice, and humans with a more pronounced effect on REM sleep observed in cats establishing the species-dependent variation in DSIPs sleep-promoting profile that remains relevant to experimental design today
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This dual action creates conditions favorable for slow-wave sleep, the deepest and most restorative sleep phase
DOI: 10.1182/blood-2006-09-048728 74
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