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We demonstrate mechanistically the need for increased mitochondrial function, facilitated by mTORPGC1-mediated mitochondrial biogenesis, to support rebalancing of pyrimidines via UCK2 to support cellular survival in the face of continued 5FU treatment
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The researchers analyzed thousands of electronic medical records of older adults with both diabetes and cancer and found that those who were taking GLP-1s had lower all-cause mortality than did those who were taking another type of diabetes medication, dipeptidyl peptidase 4 inhibitors (DPP-4i)
The use of non-model Drosophila species to study natural variation in TOR pathway signaling
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