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As for WT INS-1 832/3 cells, while we could measure increased ATP outputs from exendin-4-stimulated versus vehicle-treated Control shRNA-transduced islets, this effect was no longer present in islets transduced with SPHKAP shRNA (Fig
Similar to this process, mono- and polyunsaturated long-chain fatty acids stimulate GLP-1 release via certain free fatty acid receptors
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In particular, GSDME-deficiency significantly attenuated the hippocampal atrophy and changed levels of DAM markers in GCLC-KO mice
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