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While activating ARC AgRP/NPY neurons has been shown to be both aversive [136] and rewarding [144] depending on the duration of activation, the positive valence associated with inhibiting ARC AgRP/NPY neurons [136] lends itself well to targeting these neurons for obesity drug development

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Patients interested in retatrutide should speak to their GP or specialist and may search for recruiting trials via the NIHR 'Be Part of Research' portal