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In the liver, the 25-hydroxylase enzymes (CYP2R1 and CYP27A1) convert inactive cholecalciferol to 25(OH)VD 3 (calcidiol) by carbon 25 hydroxylation 14
HCC is characterized by enhanced aerobic glycolysis and limited oxidative phosphorylation activity, contributing to reduced apoptosis and cancer progression
10.1038/s41590-020-0699-0 30 KanemuraS.SofiaE
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