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We next repeated this experimental paradigm in Gipr hypo-KO and Gipr hypo-GFP mice, combining the initiation of HFD with a combination of LIRA (or VEH) alone or LIRA (or VEH) plus GIPR antagonist peptide (GIPR-antag)

mTORC1 disruption is heavily implicated in multiple forms of MCDs, including megalencephaly disorders and tuberous sclerosis (TS) which is caused by mutations in the TSC1 or TSC2 genes (Hernandez et al., 2007

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