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Some individuals experience negative reactions and the worsening of symptoms when they begin thiamine repletion therapies using the more biologically available formulations like thiamine tetrahydrofurfuryl disulfide (TTFD)
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Nrf2 is expressed by nearly all cell types, where its function is suppressed and sequestered in the cytosol by the Kelch-like Erythroid-cell-derived protein with CNC homology (ECH)-Associated Protein 1 (Keap1)
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