(Biological significance) Compared to what
Following the identification by the Armed Forces Institute of Pathology of quinine in autopsy specimens from military pilot fatalities, researchers had volunteers drink tonic water for two weeks, and were indeed able to show some abnormalities
Electrophoresis 21:21482161 Gao W, Mizukawa Y, Nakatsu N, Minowa Y, Yamada H, Ohno Y, Urushidani T (2010) Mechanism-based biomarker gene sets for glutathione depletion-related hepatotoxicity in rats
(7) D A York, S Boghossian, and M Park-York (2011) Melanocortin activity in the amygdala influences alcohol intake Pharmacology, Biochemistry & Behavior, 2011 Mar, Volume 98 (Issue 1), Pages 112-9