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Therefore, PPAR may interact with FXR, thereby inhibiting the regulation of bile acid homeostasis by FXR (Table 1 summarizes key BAs receptors, their ligands, signaling mechanisms, and physiological roles

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At the same time, semaglutide slows glucose absorption into the bloodstream by reducing the speed at which the stomach empties after eating

The aromatase encoded by the CYP19A1 gene is a key rate limiting enzyme in the estradiol (E2) synthesis pathway