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As expected, administration of BSO in the established high ACTL6A-expressing PDX tumors (cases 1 and 3) attenuated tumor progression
Navolanic PM, Steelman LS, Leslie NR, Coffer PJ, Konopleva M, Hu W, Andreeff M , Blagosklonny MV, McMahon M, McCubrey JA
The UPR has three canonical branches (PERK/ATF4, IRE1a/XBP1, and ATF6), which play a central role in mitigating cellular stress by enhancing protein folding capacity and secretion, activating the oxidative stress response, and inducing autophagy, thereby restoring protein homeostasis (137)
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