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What the Trials Measured Study 1 in the Wegovy label the large cardiovascular outcomes trial in 8,801 and 8,803 participants reported mean changes at week 104 including a systolic blood pressure reduction of 3.8 mmHg with semaglutide from a baseline of 131 mmHg, versus 0.5 mmHg with placebo, a difference of 3.3 mmHg