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Nonetheless, with greater weight loss and decreased body fat, both cortisol production and free cortisol levels increased, whilst adipose 11-HSD-1 decreased, compared to baseline (78)
In a small-scale four-week long, open-label study involving 14 individuals diagnosed with major depressive disorder and bipolar disorder, which also displayed impaired executive function, treatment with liraglutide significantly reduced Hamilton Depression Rating Scale (HDRS) scores and improved executive function, however, at the same time it did not improve cognitive function in patients [122]
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