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Epitalon was also found to downregulate HER-2/neu gene expression, likely through modulation of chromatin structure or transcriptional regulation
Proper handling and storage help minimize degradation processes such as hydrolysis, oxidation, and peptide aggregation, which can affect experimental consistency
The result is a modest, surface-level improvement better than most skincare ingredients, but limited by the delivery method
Additionally, environmental factors such as iodine excess or deficiency, smoking, stress, exposure to chemicals, medications (e.g., amiodarone, interferon-), and some viral/bacterial infections can alter gene expression patterns through epigenetic mechanisms and trigger autoimmune processes
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