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Oral administration of Lactobacillus reuteri GMNL-263 improves insulin resistance and ameliorates hepatic steatosis in high fructose-fed rats

Novo Nordisks Wegovy is available as multiple-dose pre-filled pens that deliver a preset dose for once-weekly dosing, while Ozempic is available as multiple-dose pre-filled pens for single-patient use, designed for once-weekly dosing

This consistent presence allows the drug to continuously regulate appetite, slow gastric emptying, and improve blood sugar control

The two treatments operate through completely separate mechanisms: semaglutide acts on GLP-1 receptors in pancreatic, gastrointestinal, and central nervous system tissues, whilst botulinum toxin blocks acetylcholine release at peripheral nerve terminals