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Vehicle-treated Gipr fl/fl and Gipr Syn/ mice showed a 1.5% and 2.6% weight gain, respectively, whereas mGIPR-Ab/P1-treated Gipr fl/fl mice lost 20% of their body weight (Fig

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Following exenatide treatment, fasting proinsulin decreased, indicating a lower demand of insulin from the periphery and less stress on the -cells

From a neuropsychiatric perspective, I would add that, in my opinion, this class of medications might also prove efficient for the treatment of acute manic episodes in bipolar disorder