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These specialized regions relay peripheral signals into deeper brain areas without direct engagement of preproglucagon (PPG) neurons, which constitute the brains endogenous GLP-1 source (McLean et al., 2021)
Tirzepatide and the IS were detected using multiple reaction monitoring (MRM) at transitions m / z 1204.3396.2 and 1029.51238.8, respectively, with a dwell time of 200 ms per MRM channel
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