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Dysregulated IL-6 signaling contributes to pathogenic inflammation in autoimmune diseases such as rheumatoid arthritis and idiopathic juvenile arthritis 57 and anti-IL-6R therapies such as tocilizumab are successfully used in autoimmune disease 58

The 15 mg dose of tirzepatide produced a mean percent change in weight of almost 21% by week 72, which, when youre talking about a mean baseline body weight of 105.6 kg in that group, is a LOT of kgs dropped