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The mechanistic gap in the Retatrutide vs Tirzepatide comparison is therefore not merely quantitative (one more receptor) but qualitatively significant in terms of metabolic coverage and fat oxidation pathways
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Moreover, the observation that adding GLP-1MK-801 treatment on top of semaglutide leads to an additional weight loss of 7% in mice that have reached a weight loss plateau with semaglutide provides additional support for integrating NMDA receptor antagonism in next-generation weight loss therapeutics
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