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Although the purpose of the study was not to conduct quantitative analyses, questionnaire data showed a trend towards reduction in PHQ-9, GAD-7 and EDE-Q scores (Table 1), which were clinically significant given that change scores of 5, 4 and 0.57 are considered the minimal clinically important differences in PHQ-9, GAD-7 and total EDE-Q scores respectively [38,39,40]
Each 10 units = 250mcg
Given the importance of hyperandrogenism-hyperinsulinemia in PCOS, most of the current therapeutic strategies aim at reducing androgen excess by improving insulin sensitivity, mainly via lifestyle changes and/or pharmacological approaches
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