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In addition, methylxanthine compounds, such as theobromine and caffeine, are powerful antioxidants
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The velocity of GS, the synthesizing enzyme, is not affected by estradiol
Furthermore, NADPH is replenished by the isocitrate dehydrogenase (IDH1/IDH2) branch of the citric acid cycle (TCA cycle), malic enzyme (ME1), and one-carbon metabolism (such as the folate cycle) depending on cell type or nutritional status
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