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So far, semaglutide (Wegovy) shows the most significant weight loss among approved GLP-1s: Average weight loss: 15 percent or more of body weight over time Administered once weekly Tirzepatide (Mounjaro), though not a pure GLP-1, has shown even greater weight loss in trials and was approved by the FDA specifically for weight management under the name Zepbound
Gulyaeva NV (2021) Glucocorticoid Regulation of the Glutamatergic Synapse: Mechanisms of Stress_Dependent Neuroplasticity
These effects are primarily linked to their ability to reduce oxidative stress, modulate neuroinflammation and improve cognitive function in various cellular and animal models [3, 54]
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