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On the flip side, if the plateau comes with solid lab results, better energy, and improved quality of life, maintaining your current weight might be the win

Because retatrutide is dose-escalated gradually in trial protocols, participants who are unable to tolerate higher doses due to side effects may not achieve the same degree of weight loss as those who reach the target maintenance dose

One notable example is Zodasiran, which has shown encouraging results in the ARCHES-2 trial

adverse effects were broadly consistent with GI tolerability known for GLP-1/dual agonists, with higher discontinuation during rapid dose escalation