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doi: 10.1073/pnas.1412271111
These mural cells, located on the abluminal side of the EC layer, include vascular smooth muscle cells around the large vessels, astrocytes and pericytes, which are embedded in the basement membrane and cover the abluminal side of the endothelial wall with their processes ( The basement membrane, composed of collagen type IV, laminin, fibronectin and heparan sulfate proteoglycan, separates ECs from other cellular members interacting with them
Help retain moisture in the skin, making it decays
152 Additionally, cleavage to form the active drug may not occur at a sufficient rate and with the necessary accuracy to produce localized therapeutic concentrations of the drug
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