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Impure peptide preparations can introduce experimental confounders, as degradation products or synthesis byproducts may have their own biological activities or interfere with receptor binding assays

Repeated ketamine anesthesia during the neonatal period impairs hippocampal neurogenesis and long-term neurocognitive function by inhibiting mfn2-mediated mitochondrial fusion in neural stem cells

There is one small pilot study in humans (examining knee pain, where 7 of 12 participants reported sustained improvement beyond 6 months) and a 2025 safety study confirming BPC-157 was well tolerated in healthy adults

reported a rational design of two AAV9 variants for brain drug delivery