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PCs are synthesized by phytochelatin synthase (EC 2.3.2.15) in cytosol with GSH as the precursor
Nat Rev Neurosci Jun 2014;15(6):367-78
M1-dominant macrophages overproduce TNF- and IL-6, directly blocking insulin receptor signalling in metabolically active tissues [4]
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We also attempted replication analysis in the UK Biobank cohort, although the available data predate the availability of semaglutide or tirzepatide, and hence relied on earlier variants of GLP1 receptor agonists
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