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Dihexa was administered intraperitoneally (i.p.) at 0.5 mg/kg in phosphate buffered saline (PBS) on alternate days, commencing 15 days post-surgery and continuing through day 48, with control animals receiving PBS alone
At 10 to 12 mg daily The highest sublingual doses carry side effect profiles comparable to the 12.5 to 15 mg injectable range
In mouse models of lupus, treatment with these peptides reduced lupus nephritis severity and decreased B cell activation
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