Thus, damage to mitochondrial DNA and loss of can further increase ROS production, thereby creating a cycle of dysfunction that includes increased ROS production by the respiratory chain, activation of signal transduction pathways, and potentially, leading to apoptosis or necrosis, as well as the release of cytochrome c, which triggers apoptosis
doi:10.1016/j.dadr.2023.100195 Jerlhag E
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Consequently, despite the clear message of landmark trials such as the Diabetes Control and Complications Trial and the UK Prospective Diabetes Study regarding the need for excellent glycemic control, diabetes remains the leading cause of blindness, renal failure, and amputations