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There is also a 5-year Phase III clinical trial (NCT04822181) underway to investigate the efficacy and safety of semaglutide monotherapy in patients with NASH without cirrhosis, assessing the primary endpoints of progression of cirrhosis, regression of steatohepatitis, inflammation, and histological changes in balloon-like hepatocytes
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Its primary mechanism involves binding to actin the structural protein that makes up muscle fibres and promoting cell migration, new blood vessel formation, and the proliferation of cells critical to wound healing
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