discontinuing semaglutide GLP-1 drugs work while you're on them. The problem is what happens when you stop. Clinical trials show two-thirds of people regain the weight within a year of stopping — and Stopping Semaglutide Safely: Biomarker &

Osteoblast-related gene expression of bone marrow cells during the osteoblastic differentiation induced by type I collagen

Your provider can use this information alongside clinical assessments to determine whether donation is safe at your current GLP-1 dose and whether timing adjustments would be prudent

Take naproxen with food to reduce gastric irritation, maintain adequate hydration, use the lowest effective dose for the shortest duration, and consider gastric protection with a proton pump inhibitor if you have risk factors such as age over 65 or history of peptic ulcer disease

However, severe constipation persisting beyond 3 weeks, abdominal pain, rectal bleeding, or signs of bowel obstruction require immediate medical attention