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The initial phase of treatment usually involves higher and more frequent doses to quickly restore healthy vitamin B12 levels
The Phase 2 trial reference point The Phase 2 retatrutide trial (Jastreboff et al., New England Journal of Medicine 2023) enrolled 338 adults across placebo and retatrutide arms at 1, 4, 8, and 12 mg weekly
The medication treats obesity the way blood pressure medication treats hypertension, continuously
However, we need more research in this area to figure out exactly how each substance contributes to the overall result
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