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The only published dosing protocol is from mouse studies: 5 mg/kg by intraperitoneal injection, given intermittently over weeks
These can include dry mouth, headaches, agitation, and in rare cases, an increased risk of seizures, which is dose-dependent
The primary mechanism of NO mediated wound healing is the formation of new blood vessels in a process called angiogenic repair
However, human clinical evidence is still limited, and larger, well-controlled trials are needed to clarify safety, efficacy, and appropriate use
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