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But this reflects the near-total absence of systematic safety surveillance rather than proof of a benign profile
Sex hormone and androgen-metabolite induction of Src, Raf-1, ERK1/2, MEK, and CREB activation [126, 127] were mediated by androgen and estradiol treatment-induced AR association (within 1-min) to the SH3 kinase domain of Src in cancer cell lines [124]
At the clinical translation level, in addition to using classic surface markers such as CD90 and CD73 to establish the identity of MSC-Exos (128), clinical trials further indicate that a reduction in plasma Angiopoietin-2 (Ang-2) levels suggests improvement in endothelial injury and is closely related to the biological effects of MSC therapy (129), allowing it to be constructed as a precise molecular ruler for assessing tissue repair potential
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