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Glutathione inhibits tyrosinase, an enzyme in melanin production, which can gradually lead to more even skin tone and reduced dark spots
On one hand, a large 2024 cohort study (over 160,000 patients with obesity) reported a significantly higher incidence of new psychiatric diagnoses among GLP-1 RA users: an ~98% increase in risk of any psychiatric disorder compared to matched non-users, including a 195% higher risk of major depression and ~106% higher risk of suicidal behavior (Scientific Reports 2024)
DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption
