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Retatrutide is an investigational triple incretin receptor agonist targeting GLP-1, GIP, and glucagon receptors to reduce appetite and body weight, while tesamorelin is a growth hormone-releasing hormone analogue that stimulates pituitary GH release to reduce visceral fat, primarily in HIV-positive patients with lipodystrophy
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Amgen's 2026 real-world evidence presentations noted that GLP-1 benefits are closely tied to sustained treatment use, while many patients discontinue within the first year in routine practice
Stratifying the data by life stage indicated that young children ages 2-8 years were more likely to meet the AI than older children, adolescents, or adults (107)
