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When a too high concentration of antioxidants (e.g., ascorbate) is used, a switch from antioxidant to prooxidant behavior may occur, especially under certain conditions (e.g., highly oxygenated tissues such as lungs or the presence of redox-active metals such as Cu or Fe)

The work of the latter authors has opened the field for further research regarding the role of L-carnitine supplementation in seizure control

Treatment with hederagenin in lung cancer cells, leads to a strong upregulation of the CHAC1 gene even though basal CHAC1 expression is significantly lower than in normal tissues (Lu et al., 2024)